Pyrazinamide deamidase activity in tuberculous disease

Gurumurthy, Prema and Krishnamurthy, P V and Raghupati Sarma, G (1981) Pyrazinamide deamidase activity in tuberculous disease. American Review of Respiratory Diseases, 124 (1). p. 97. ISSN 0003-0805

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Abstract

To investigate whether pyrazinamide deamidase activity is suppressed in tuberculosls, serial serum concentrations of pyrazinamide, following 40 mg of pyrazinamide per kg, were determined in 10 patients with-sputum positive pulmonary tuberculosis and in 10 control subjects without disease. The concentrations and the half-lives of pyrazinamide were similar in the 2 groups, suggesting no suppression of the deamidase activity in tuberculous patients.

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