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Lack of Relationship between Hepatic Toxicity and Acetylator Phenotype in Three Thousand South Indian Patients during Treatment with lsoniazid for Tuberculosis

Gurumurthy, Prema and Krishnamurthy, M S and Nazareth, O and Parthasarathy, R and Raghupati Sarma, G and Somasundaram, P R and Tripathy, S P and Ellard, G A (1984) Lack of Relationship between Hepatic Toxicity and Acetylator Phenotype in Three Thousand South Indian Patients during Treatment with lsoniazid for Tuberculosis. American Review of Respiratory Diseases, 129 (1). pp. 58-61. ISSN 0003-0805

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Abstract

The results are presented of a retrospective analysis of the incidence of jaundice among 3,000 patients with pulmonary tuberculosis and of the activities of serum aspartate aminotransferase among 850 according to their isoniazid acetylator phenotype. The patients had been treated with a variety of isoniazid-containing regimens in a series of controlled clinical trials in South India. The results show that rapid acetylators are no more prone to develop isoniazid-induced hepatic toxicity than are slow acetylators.

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Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Biochemical,Clinical and Pharmacological
Tuberculosis > Clinical Research
Divisions: Basic Science Research > Biochemistry and Pharmacology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 07 Aug 2013 08:41
Last Modified: 17 Mar 2016 09:04
URI: http://eprints.nirt.res.in/id/eprint/174

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