Humoral immunity in acute post-streptococcal glomerulonephritis

Rajajee, S and Narayanan, P R and Moses, S G P and Sundaravalli, N (1984) Humoral immunity in acute post-streptococcal glomerulonephritis. Indian Pediatrics, 21 (9). pp. 677-681. ISSN Print: 0019-6061; Online:0974-7559

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children with acute post-streptococcal glomerulonephritis in parallel with IS children with only skin streptococcal infection and 20 normal children. B-lymphocytes as assessed by EAC rosettes estimation was significantly elevated in patients. Markedly high anti-DNase B antibody titres were demonstrated in patients and to a less extent in skin infection controls, as compared to normal controls. C3 levels were decreased in all the patients and C4 levels were decreased in 76%. The levels returned to normal 2 months later. C3 and C4 levels were normal in skin infection and normal controls. Serum IgG, IgM, IgA were normal in patients and Rheumatoid factor was positive in only 24% o f patients, all of whom had a low positive titre. These studies indicate marked humoral immune response to streptococcal infection in patients with APSGN. IgG anti-IgG immune complex did not play a sign&ant role in our patients.

Item Type: Article
Uncontrolled Keywords: Acute post-streptococcal glomerulonephritis, Humoral immunity
Subjects: Tuberculosis > Laboratory Research > Immunological
Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 07 Aug 2013 10:12
Last Modified: 17 Mar 2016 09:08

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