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Cell mediated immune response in South India pulmonary tuberculosis patients

Paranjape, R S and Ravoof, A and Acharyulu, G S and Krishnamurthy, P V and Tripathy, S P and Prabhakar, R and Narayanan, P R (1988) Cell mediated immune response in South India pulmonary tuberculosis patients. Indian Journal of Tuberculosis, 35 (4). pp. 163-170. ISSN 0019-5705

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Abstract

Ninety-two untreated pulmonary tuberculosis (TB) patients and sixty two non-tuberculous (non-TB) controls drawn from the same socio-economic strata were studied for their delayed hypersensitivity (DH), cell mediated immunity (CMI) and bacillary-load. There was no correlation between bacillary load and response in parameters of CMI, namely, lymphocyte transformation test (LTT) and leucocyte migration inhibition test (LMI). Migration Index (MI) in LMI did not correlate with DH in TB patients. There was no significant difference in the mean values of MI between TB and non-TB control patients. Response of lymphocytes to mitogens and percentage of T-rosetting cells also did not differ between TB and non-TB control patients. On the contrary, differences were found in the two groups of patients with regard to lymphocyte response to PPD antigen and mean B-cell percentage. While, among non-TB patients. high Mantoux reactors had significantly higher LTT response to PPD compared to low Mantoux reactors: no such difference was observed among TB patients. The mean B-Cell percentage was significantly higher in TB patients than in non-TB controls. The relevance of these differences in relation to tuberculosis in discussed.

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Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 23 Aug 2013 06:44
Last Modified: 15 Mar 2016 05:56
URI: http://eprints.nirt.res.in/id/eprint/238

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