Hydrogen peroxide producing potential of alveolar macrophages & blood monocytes in pulmonary tuberculosis

Selvaraj, P and Raji, Swamy and Vijayan, V K and Prabhakar, R and Narayanan, P R (1988) Hydrogen peroxide producing potential of alveolar macrophages & blood monocytes in pulmonary tuberculosis. Indian Journal of Medical Research, 88 (August). pp. 124-129. ISSN 0971-5916

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Abstract

Alveolar macrophages from patients with active pulmonary tuberculosis, inactive tuberculosis (treated patients), non-tuberculous lung disease and from normal healthy individuals were tested for their ability to produce hydrogen peroxide (H2O2) upon stimulation with phorbol myristate acetate (PMA) in vitro. PMA induced H2O2 production was significantly higher in all the groups of patients studied when compared to the normal subjects. Among the four groups studied, the spontaneous release of H2O2 was increased in the alveolar macrophages of smokers than non-smokers. There was no difference in the spontaneous and PMA induced H2O2 production between the non-smoker group of the active tuberculosis patients and the normal non-smoker group. Further, the blood monocytes of the activepulmonary tuberculosis patients and those of normal controls were equally competent in producing H2O2, in vitro, upon stimulation with PMA. The study suggests that the increased production of hydrogen peroxide by alveolar macrophages is not specific for tuberculosis.

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