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Alveolar macrophages in patients with pulmonary tuberculosis

Selvaraj, P and Venkataprasad, N and Vijayan, V K and Prabhakar, R and Narayanan, P R (1988) Alveolar macrophages in patients with pulmonary tuberculosis. Lung India, 6 (2). pp. 71-74. ISSN Print: 0970-2113; Online: 0974-598X

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Total and HLA-DR positive alveolar macrophages were enumerated in the broncho-alveolar lavage fluids of active pulmonary tuberculosis, inactive pulmonary tuberculosis (treated cases), nontuberculous lung disease patients and normal healthy individuals. A significantly increased number of macrophages was found in the patient groups than the normal individuals: however, there was no difference in HLA-DR positive cells. Among the different patient groups, smokers had more macrophages as well as more HLA-DR positive macrophages than non-smokers and normal subjects Total number of alveolar macrophages of the active tuberculosis non-smoker group was significantly higher than the inactive tuberculosis non-smoker group and normal individuals. On the contrary, a slightly decreased number of HLA-DR positive cells was seen in the non-smoker group of active-TB patients. The present study suggests that infection and smoking induce the accumulation of macrophages in the lung. The implication of these findings in relation to tuberculosis is discussed.

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Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 23 Aug 2013 11:17
Last Modified: 15 Mar 2016 05:59

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