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Age for measles immunization seroconversion after measles vaccination at 6-8 months of age - A randomised controlled trial

Deivanayagam, N and Ramamurthy, N and Krishnamurthy, P V and Shankar, V J and Ashok, T P and Nedunchelian, K and Mala, N and Shaffi Ahmed, S (1990) Age for measles immunization seroconversion after measles vaccination at 6-8 months of age - A randomised controlled trial. Indian Pediatrics, 27 (Nov). pp. 1171-1176. ISSN Print: 0019-6061; Online:0974-7559

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Abstract

The, objective of the study was to compare the effectiveness of measles vaccine by seroconversion in vaccinated children with non-vaccinated children of 6 to 8 months age group in a city slam community so as to study the feasibility of advancing the age of immunization. Live attenuated lyophilized Schwartz strain of measles vaccine was used. Hemagglutination inhibition (HI) antibody was estimated. Seroconversion was defined as either the conversion of negative to positive or a two fold rise in titre. One hundred and thirty two children completed the study. There was no difference in the age, sex and nutritional status between vaccinated and non-vaccinated groups (p>0.7). The seroconversion rate in the vaccinated group was 65% and in the non-vaccinated group was 26%. The age, sex and nutritional status did not significantly affect the seroconversion. Oar data suggest that immunization with measles vaccine may be effective as early as 6 months of age. Immunization at 6 months may be needed at least for children in densely populated areas like cities and towns.

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Item Type: Article
Uncontrolled Keywords: Seroconversion, Measles Infants, Community. vaccine
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 30 Aug 2013 08:13
Last Modified: 14 Mar 2016 09:25
URI: http://eprints.nirt.res.in/id/eprint/271

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