Promoting Open Access to Exploring the Research

Gastro-intestinal absorption of isoniazid and rifampicin in patients with intestinal tuberculosis

Gurumurthy, Prema and Ramachandran, Rajeswari and Balasubramanian, Rani and Rahman, Fathima and Victor, Lalitha and Narayana, A S L and Raghupati Sarma, G (1990) Gastro-intestinal absorption of isoniazid and rifampicin in patients with intestinal tuberculosis. Indian Journal of Tuberculosis, 37 (5). pp. 5-10. ISSN 0019-5705

[img]
Preview
PDF
199015.pdf - Published Version

Download (132kB)
Official URL: http://lrsitbrd.nic.in/indian_journal_of_tuberculo...

Abstract

The gastro-intestinal absorption of isoniazid and rifampicin was studied in 12 patients with intestinal tuberculosis (10 slow and 2 rapid acetylators of isoniazid) and compared with that in 18 patients with pulmonary tuberculosis (8 slow and 10 rapid acetylators). Exposure (area under the time-concentration curve), calculated on the basis of serum concentrations of the two drugs at 1, 2, 3, 6 and 8 hours, and the proportion of dose of isoniazid excreted in urine collected over the period (0-8½) hours as isoniccotinyl compounds after drug administration were similar in the 2 groups suggesting no impairment of gastro-intestinal absorption of the 2 drugs in patients with intestinal tuberculosis. It was also observed that there was no delay in the absorption of the 2 drugs in patients with intestinal tuberculosis as compared to that in patients with pulmonary tuberculosis. The absorption of D-xylose, used to assess the absorptive capacity of the proximal small intestine, was also similar and normal in both groups of patients.

NIRT Creators:
NIRT CreatorsEmail
Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Biochemical,Clinical and Pharmacological
Divisions: Basic Science Research > Biochemistry and Pharmacology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 30 Aug 2013 09:46
Last Modified: 14 Mar 2016 09:27
URI: http://eprints.nirt.res.in/id/eprint/277

Actions (login required)

View Item View Item