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Five year results of a 3-month and two 5-month regimens for the treatment of sputum-positive pulmonary tuberculosis in South India

Balasubramanian, Rani and Sivasubramanian, S and Vijayan, V K and Ramachandran, Rajeswari and Jawahar, M S and Paramasivan, C N and Selvakumar, N and Somasundaram, P R (1990) Five year results of a 3-month and two 5-month regimens for the treatment of sputum-positive pulmonary tuberculosis in South India. Tubercle, 71 (4). pp. 253-258. ISSN 0041-3879

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Abstract

A controlled study of three short-course regimens was undertaken in South Indian patients with newly diagnosed, sputum-positive pulmonary tuberculosis. The patients were allocated at random to one of three regimens: a) Rifampicin, streptomycin, isoniazid and pyrazinamide daily for 3 months (R3); b) the same regimen as above but followed by streptomycin, isoniazid and pyrazinamide twice-weekly for a further period of 2 months (R5); c) the same as R5 but without rifampicin (25). A bacteriological relapse requiring treatment occurred by 5 years in 16.8% of 113 R3,5.2% of 97 R5, and 20.0% of 115 25 patients with organisms sensitive to streptomycin and isoniazid initially. The differences in the relapse rates between the R3 and R5 regimens and the R5 and 25 regimens were statistically significant (p < 0.01 for both). Considering patients with organisms initially resistant to streptomycin or isoniazid or both, 7 of 52 patients (4 R3,2 R5,l 25) had a bacteriological relapse requiring retreatment.

NIRT Creators:
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Item Type: Article
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 30 Aug 2013 10:24
Last Modified: 14 Mar 2016 09:25
URI: http://eprints.nirt.res.in/id/eprint/282

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