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Pulmonary membrane diffusing capacity and capillary blood volume in tropical eosinophilia

Vijayan, V K and Kuppurao, K V and Venkatesan, P and Sankaran, K and Prabhakar, R (1990) Pulmonary membrane diffusing capacity and capillary blood volume in tropical eosinophilia. Chest, 97 (6). pp. 1386-1389. ISSN Print: 0012-3692; Online: 1931-3543

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Abstract

Pulmonary membrane diffusing capacity (Dm) and pulmonary capillary blood volume (Vc) measurements were carried out in 21 patients with untreated tropical eosinophilia and 21 healthy controls matched for age, sex, height, and smoking habit. The mean single breath transfer factor (Dco) and the mean membrane diffusing capacity were significantly lower (p<0.001) in patients with tropical eosinophilia compared with control subjects. However, the mean capillary blood volume was not significantly different (p>0.2). The positive correlations between Dm and transfer factor (r=0.825), between Dm and effective alveolar volume (Va) (r=0.721), and between Dco and VA (r=0.774) were also highly significant (p<0.001) in study patients prior to treatment. These data suggest that reduction in single breath transfer factor in untreated tropical eosinophilia may be due to a reduction in membrane diffusing capacity, which in turn may be due to a reduction in area of membrane available for diffusion, as evidenced by the significantly reduced VA (p<0.001) in these patients. Since pulmonary capillary blood volume was normal, the pulmonary perfusion was within normal limits. Following three weeks of treatment with diethylcarbamazine citrate, although there was a significant rise in single breath transfer factor (p<0.001) and membrane diffusing capacity (p<0.05), both Dco (p<0.01) and Dm (p<0.01) continued to be significantly lower than those of control subjects. However, pulmonary capillary blood volume did not show any change (p>0.2).

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Item Type: Article
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 30 Aug 2013 11:01
Last Modified: 14 Mar 2016 09:33
URI: http://eprints.nirt.res.in/id/eprint/285

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