Raghupati Sarma, G
(1991)
Effect of administration of rifampicin on the adrenocortical function in patients with pulmonary tuerculosis.
Indian Journal of Tuberculosis, 38 (2).
p. 105.
ISSN 0019-5705
Abstract
The ACTH (synacthen) stimulation test was
performed on admission and after 4 weeks of
treatment in 17 pulmonary tuberculosis patients
receiving daily Rifampicin regimen (R-7), 22
patients on a twice-weekly Rifampicin regimen
(R-2) and 19 patients on a daily non Rifampicin
regimen (NR-7). A positive response to
synacthen was observed in 8 R-7, 16 R-2 and 8
NR-7 patients on admission and in 7, 15 and 15
patients respectively at 4 weeks. The increase in
the proportion of positive responders among the
NR-7 patients was significant (P = 0.02). Three
R-7 and 2 R-2 patients who were positive
responders to synacthen on admission became
negative responders at 4 weeks, a phenomenon
not observed in the NR-7 patients. These findings
suggest that Rifampicin probably exerts a
deleterious effect on the adrenocortical function.
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