Maternal fetal immunological relationship particularly mycobacterial immunity

Rajajee, S and Sundareswar, S (1991) Maternal fetal immunological relationship particularly mycobacterial immunity. Indian Pediatrics, 28 (4). pp. 363-366. ISSN Print: 0019-6061; Online:0974-7559

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Thirty-nine paired maternal and cord blood from normal full term deliveries were tested for lymphocyte function by proliferative response to mitogens – Phytohemagluttin-P (PHA) and Poke weed mitogens (PWM). Monocyte function was assessed by the ability of the monocytes to release hydrogen peroxide (H 2O2 ) in response to standard stimulus (PMA). Mycobacterial immunity was assessed by lymphocyte proliferative response to purified proteins derivative (PPD) and IgM and IgG antibody response to H37Rv and 5 atypical mycobacteria. Lymphocyte functions were significantly lower in cord blood (PHA 20.6, PWM 21.2) as compared with maternal blood (PHA 65.8, PWM 37.8). The capacity of fetal monocytes to release H2O2 was comparable to maternal monocytes. The mean proliferative response of fetal lymphocytes to tubercular protein (PPD) was 0.67 as compared (P< 0.01) tO maternal lymphocytes (3.79). Nearly 86% of the cord blood did not show any response to PPD. None of the cord blood showed IgM antibody response to H37RV nor to any of the range of 5 atypical mycobacteria though maternal IgM and IgG response was present. There was only passive transfer of IgG antibody from mother to fetus. Hence, though this is a highly endemic area for atypical mycobacteria and M. tuberculosis, there was apparently 170 transplacental transfer of antigen in normal sensitized mothers.

Item Type: Article
Uncontrolled Keywords: Immunity, Mycobacteria, Matemofetal transfer.
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 04 Sep 2013 06:25
Last Modified: 14 Mar 2016 08:41

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