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No association or linkage with HLA-DR or -DQ and genes in South India with pulmonary tuberculosis

Sanjeevi, C B and Narayanan, P R and Prabhakar, R and Charles, N and Thomas, B E and Balasubramanian, R and Olerup, O (1992) No association or linkage with HLA-DR or -DQ and genes in South India with pulmonary tuberculosis. Tubercle and Lung Disease, 73 (5). pp. 280-284. ISSN 0962-8479

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Studies of the HLA class II genes were performed in patients and multiple families with pulmonary tuberculosis from South India to seek any association of disease susceptibility with an individual allele or haplotype. Taq I RFLP analysis of HLA-DRB, -DQA and -DQB genes was done in 38 patients and 36 healthy control subjects. No significant association with any particular allele or haplotype was obtained. Linkage analysis performed in 12 families and haplotype sharing analysis in 9 families showed that the genetic susceptibility to pulmonary tuberculosis was not linked to the HLA region. The results suggest that the RFLP patterns of HLA class II genes DRB, DQA and DQB are not associated with susceptibility to pulmonary tuberculosis and that the genes controlling susceptibility or resistance may be located outside the HLA region.

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Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 11 Sep 2013 11:17
Last Modified: 14 Mar 2016 07:28

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