Effect of iron on the growth and siderophore production of mycobacteria

Raghu, B and Raghupati Sarma, G and Venkatesan, P (1993) Effect of iron on the growth and siderophore production of mycobacteria. Biochemistry and Molecular Biology International, 31 (2). pp. 341-348. ISSN 1039-9712

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To gain a better understanding of the role of iron in the pathogenesis of tuberculosis, the growth and production of siderophores were studied in the presence of different concentrations of free iron in vitro with M. smegmatis and virulent, avirulent and low virulent strains of M. tuberculosis. Increase in the concentrations of iron caused an appreciable increase in the growth (as assessed by cell dry-weight and log viable counts) of all 4 strains. This was, however accompanied by a significant decrease in the production of both exochelins and mycobactins, suggesting that these siderophores are necessary only under iron-deficient conditions. The growth and production of siderophores were significantly higher with the virulent strain of M.tuberculosis than with the avirulent (or) the low virulent strains.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Biochemical
Divisions: Basic Science Research > Biochemistry
Depositing User: Dr. Rathinasabapati R
Date Deposited: 20 Sep 2013 10:48
Last Modified: 14 Mar 2016 06:40
URI: http://eprints.nirt.res.in/id/eprint/344

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