Altered bactericidal activity aginst staphylococcus aureus in tuberculous bronchoalveolr lavage fluids

Selvaraj, P and Venkataprasad, N and Vijayan, V K and Narayanan, P R (1994) Altered bactericidal activity aginst staphylococcus aureus in tuberculous bronchoalveolr lavage fluids. European Respiratory Journal, 7 (1). pp. 121-126. ISSN Print: 0903-1936; Online: 1399-3003

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Abstract

Altered bactericidal activity against Staphylococcus aureus in tuberculous bronchoalveolar lavage fluids. P. Selvaraj, N. Venkataprasad, V.K. Vijayan, P.R. Narayanan. ©ERS Journals Ltd 1994. ABSTRACT: We wished to evaluate the pulmonary defence capacity against common bacterial infections in patients with pulmonary tuberculosis. Bactericidal activity against Staphylococcus aureus of bronchoalveolar lavage fluids (cell-free supernatants) of patients with active (n=13) and inactive pulmonary tuberculosis (n=8), and normal individuals (n=6), were studied. The 2 and 4 h bactericidal activities were higher than the 0 h activity in lavage fluids of healthy subjects and patients with inactive pulmonary tuberculosis. Active tuberculous lavage fluids were equally competent in their bactericidal activity against S. aureus at 0 and 2 h, but a reduced S. aureus hilling was seen at 4 h of incubation. Estimation of total phospholipid levels revealed no significant difference between the various lavage fluids. This reduced hilling of S. aureus showed a relationship with the cellular components (lymphocytes and macrophages) of active tuberculous lavage fluids. A reduced hilling was associated with no lymphocytic alveolitis, and an increased hilling with lymphocytic alveolitis. This study suggests that alveolar lining material of patients with active pulmonary tuberculosis has less bactericidal activity against bacterial infections, such as S. aureus.

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