Characterization of airway inflammation in stable bronchial asthma

Vijayan, V K and Subramaniam, P and Venkatesan, P and Sankaran, K and Gnanaguruparan, K S (1995) Characterization of airway inflammation in stable bronchial asthma. Lung India, 13 (3&4). pp. 132-135. ISSN Print: 0970-2113; Online: 0974-598X

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Fifty stable mild bronchial asthma patients were studied to characterize the airway inflammation using the technique of bronchoalveolar lavage (BAL). 18 normal non-smoking subjects were studied as control subjects. Total inflammatory cells (29.6±18.4 x 106 /dl vs 16.0±6.6 x 106/dl, p(<0.001), absolute macrophages (24.5±15.9 x 106/dl vs 13.3 ± 5.5 x 106/dl. p<0.001), eosinophils (1.0±1.5 x 106 dl vs 0.1±0.1 x 106/dl, p<0.001) and lymphocytes (3.8±4.2 x 106/dl vs 2.4±1.5 x 106/dl, p<0.05) were significantly higher in BAL fluid from patients with bronchial asthma compared to normal control subjects. Abnormally elevated eosinophils (>4%) and lymphocytes (>28%) in BAL fluid were seen in 15 (30%) and five (10%) patients respectively. This study demonstrates that chronic lung inflammation characterised by abnormally elevated macrophages, eosinophils and lymphocytes persists even in patients with stable mild bronchial asthma, despite medication with oral beta stimulants or theophylline.

Item Type: Article
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 27 Sep 2013 06:24
Last Modified: 14 Mar 2016 05:35

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