Association of HLA-Class I antigens and haplotypes with relapse of pulmonary tuberculosis in patients treated with short course chemotherapy

Selvaraj, P and Uma, H and Reetha, A M and Xavier, T and Venkatesan, P and Prabhakar, R and Narayanan, P R (1997) Association of HLA-Class I antigens and haplotypes with relapse of pulmonary tuberculosis in patients treated with short course chemotherapy. Indian Journal of Tuberculosis, 44 (1). pp. 9-12. ISSN 0019-5705

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Abstract

Whether or not there is an association between HLA antigen(s) and/or haplotypes aud relapse in patients successfully treated for pulmonary tuberculosis was examined. Serological determination of HLA -A, - B, -DR and -DQ antigens was carried out in patients with quiescent pulmonary tuberculosis and bacteriologically relapsed patients, after treatment with short course chemotherapy with Rifampicin, Isoniazid, Pyrazinamide and Streptomycin or Ethambutol in various combinations for 6-8 month Au increased antigen frequency of HLA -Al (P = 0.03) and B17 was seen in patients with bacteriological relapse compared with those with quiescent disease. The relative risks (RR) were Al = 2.8 and B17 = 3.2, respectively, The haplotypes Al-B17 (RR = 3.3), B17-DR7 (RR = 3.0), Al-DR7 (p = 0.04; RR = 9.3) were very common in patients with bacteriological relapse. This increase of HLA-Al, B17 antigens or the haplotypes Al- B 17, B17-DR7 or Al-DR7 (P = 0.04) was seen irrespective of the treatment regimen. The present study suggests that HLA -Al (and - B17) antigen(s), as such, and/or haplotypes Al- : DR7 or non-HLA genes linked closer to HLA -A, -B and -DR loci may be associated with relapse of pulmonary tuberculosis, after chemotherapy.

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