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HLA-DR2 phenotype and plasma lysozyme, ß-glucuronidase and acid phosphatase levels in pulmonary tuberculosis

Selvaraj, P and Kannapiran, M and Reetha, A M and Uma, H and Xavier, T and Narayanan, P R (1997) HLA-DR2 phenotype and plasma lysozyme, ß-glucuronidase and acid phosphatase levels in pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease, 1 (3). pp. 265-269. ISSN Print: 1027-3719; Online: 1815-7920

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Abstract

Tuberculosis Research Centre, Indian Council of Medical Research, Madras, India. O B J E C T I V E: To elucidate the role of HLA-Class II genes/gene products on phagocyte enzymes such as lysozyme, ß-glucuronidase and acid phosphatase in the plasma of pulmonary tuberculosis patients. DESIGN : Serological determination of HLA-DR and -DQ antigens was carried out in 54 active and 84 inactive pulmonary tuberculosis (quiescent) patients and 36 healthy control subjects. The levels of lysozyme, pglucuronidase and acid phosphatase were measured in the plasma of tuberculosis patients and control subjects. RESULTS : Increased lysozyme levels were observed in active pulmonary tuberculosis patients. ß-glucuronidase activity was higher in inactive-TB than in active-TB patients and control subjects. HLA-DR2 positive patients showed a lower lysozyme level than -DR2 negative patients. CONCLUSION: Increase in the plasma lysozyme level in active TB reveals the active stage of the disease. Further, increase in the activity of ß-glucuronidase in inactive-TB patients reveals the quiescent stage of the disease. The low level of lysozyme in HLA-DR2 positive patients may also be one of the possible factors involved in susceptibility to tuberculosis.

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Item Type: Article
Uncontrolled Keywords: HLA-DR2; lysozyme; ß-glucuronidase; acid phosphatase; pulmonary tuberculosis
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 29 Oct 2013 09:31
Last Modified: 14 Mar 2016 04:51
URI: http://eprints.nirt.res.in/id/eprint/447

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