HLA antigen profile in pulmonary tuberculosis patients and their spouses

Selvaraj, P and Uma, H and Reetha, A M and Kurian, S M and Xavier, T and Prabhakar, R and Narayanan, P R (1998) HLA antigen profile in pulmonary tuberculosis patients and their spouses. Indian Journal of Medical Research, 107 (Apr). pp. 155-158. ISSN 0971-5916

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Abstract

HLA-A, -B, -DR and -DQ antigen profile was studied in pulmonary tuberculosis patients (n=209) and their spouses (family contacts; n=50) and healthy volunteers (n=72). An increased frequency of HLAA- 10, B7, B15, DR2 and DQ1 was seen in the pulmonary-TB (PTB) patients when compared to the total control subjects (n=122). However, a significant increase was seen only with HLA-DR2 (P < 0.001; Pc < 0.01; Relative Risk 2.3) and -DQ1 (P < 0.005; Pc<0.015; Relative Risk 2.8). Among the spouses and the corresponding patients, a similar increase of HLA-DR2 was seen. A decreased frequency of HLA-A19, B8, B17, B35, DR5 and DR6 were seen in PTB as compared to control groups. The present study suggested that HLA-DR2 and DQ1 genes/gene products may be associated with the susceptibility to tuberculosis either alone or in combination with other HLA or non-HLA genes.

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