Selvaraj, P and Hill, A V S and Narayanan, P R and Reetha, A M and Colston, M J
(1998)
Non-HLA gene polymorphism in pulmonary tuberculosis.
In: Workshop on Tuberculosis Research : in to the 21st Century, 1998.
Abstract
BCG vaccination has been shown to give protection against tuberculosis.
However, South Indian (Chingleput) Trial of BCG vaccination did not give any protection
against bacillary forms of tuberculosis. A number of hypotheses and possibilities were put
forward for this failure (1). One of the possibilities suggested was the genetics of the
people (Host genetics) living in that region. Pulmonary tuberculosis is a granulomatous
lung disease caused by Mycobactrium tuberculosis. Susceptibility to tuberculosis has been
suggested to be multifactorial. Though environmental and socio-economic factors are
primarily related, numerous studies have emphasised the importance of host resistance and
hereditary susceptibility (2,3).
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