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The fate of Mycobacterium tuberculosis in activated human macrophages

Vishwanath, V and Narayanan, S and Narayanan, P R (1998) The fate of Mycobacterium tuberculosis in activated human macrophages. Current Science, 75 (9). pp. 942-946. ISSN 0011-3891

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Abstract

Human peripheral blood monocytes, that are unstimulated in vitro, permit free multiplication of intracellular Mycobacterium tuberculosis after 72 h in culture. There was no killing of bacilli in the intracellular environment even after in vitro activation of monocytes with a cocktail of lipopolysaccharide, phorbol myristate acetate, interferon gamma and tumour necrosis factor-alpha. We also tested the ability of adenosine triphosphate (ATP) in reducing the intracellular viability of mycobacteria. Infected monocytes upon ATP treatment underwent cell death, but no loss in the intracellular viability of M. tuberculosis or M. smegmatis could be observed.

NIRT Creators:
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Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 30 Oct 2013 08:52
Last Modified: 14 Mar 2016 04:38
URI: http://eprints.nirt.res.in/id/eprint/484

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