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Associations of HLA-DRB1, DQB1 and DPB1 alleles with pulmonary tuberculosis in south India

Ravikumar, M and Dheenadhayalan, V and Rajaram, K and Shanmuga Lakshmi, S and Paul Kumaran, P and Paramasivan, C N and Balakrishnan, K and Pitchappan, R M (1999) Associations of HLA-DRB1, DQB1 and DPB1 alleles with pulmonary tuberculosis in south India. Tubercle and Lung Disease, 79 (5). pp. 309-317. ISSN 0962-8479

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Setting : Tuberculosis is endemic in south India: sputum positive, pulmonary tuberculosis is predisposed by HLA-DR2 in South India and few other populations of the world. Objective : To study HLA-DRB1, DQB1, DQA1 and DPB1 allelic polymorphism in pulmonary tuberculosis patients and endemic controls from South India. Design: One hundred and twenty-six, sputum positive pulmonary tuberculosis patients and 87, endemic controls, from Madurai were studied for MHC class II allelic polymorphism by PCR-SSOP method. XI IHWC primers and probes and non-radioactive probing methods were employed. Results : HLA DRB1*1501and DQB1*0601 predisposed for pulmonary tuberculosis (DRB1*1501:odds ratio (OR) = 2.68, 95% confidence interval (CI) = 1.30 - 5.89, P value (P) = 0.013, aetiological fraction (EF) = 0.17; DQB1*0601: OR=2.32, CI=1.29-4.27, P=0.008, EF=0.26). Haplotype DRB1*1501-DQB1&0601 was higher in patients (1324 per 10,000, X2 = 27.07) than controls (F=404/10000, X2=8.84). In a subset of 63 caste cmatched samples, DPB1*04 was preventive (OR=0.45, CI=0.21-0.95, P=0.036, PF=0.26): the distributions of DRB1*1501-DQB1*0601-DPB1*04 phenotypes were different between patients and controls (P=0.0092). These alleles were predominant in patients and controls of T5SU caste. Conclusion : HLA-DRB1*1501 and DQB1*0601 predisposed to sputum positive pulmonary tuberculosis, and DPB1*04 was preventive and epistatic to this risk. Caste T5SU is an ideal model to study immunology of tuberculosis

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Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 04 Nov 2013 09:07
Last Modified: 10 Mar 2016 08:56

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