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Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India

Selvaraj, P and Narayanan, P R and Reetha, A M (1999) Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India. Tubercle and Lung Disease, 79 (4). pp. 221-227. ISSN 0962-8479

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Abstract

Setting Mannose binding protein gene polymorphism in pulmonary tuberculosis in India. Objective: To find out whether non-HLA genes such as mannose binding protein (MBP) genes are associated in the susceptibility to pulmonary tuberculosis. Design: Genotyping of MBP 52, 54 and 57 wild and mutant alleles was carried out in HLA-DR typed pulmonary tuberculosis patients (n=202) and control subjects (n=109). Since HLA-DR2 is associated with pulmonary-TB, the interaction of MBP genes on -DR2 and non-DR2 genes on the susceptibility was also studied. Results: A significantly increased genotype frequency of MBP functional mutant homozygotes (including 52, 54 and 57) was seen in pulmonary tuberculosis (PTB) patients (10.9%) than in control subjects (1.8%; P=0.008; odds ratio: 6.5). Analysis of interaction of MBP genes and HLA-DR2 on the susceptibility to PTB revealed that these genes are associated with PTB independent of each other. Conclusion: The present study shows that functional mutants of MBP are associated with PTB. Apart from HLA-DR2 association, association of non-HLA genes in the susceptibility to PTB is evident. This suggests that multigenetic factors (candidate genes) may be involved in the susceptibility/resistance to PTB.

NIRT Creators:
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Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 04 Nov 2013 09:26
Last Modified: 10 Mar 2016 08:57
URI: http://eprints.nirt.res.in/id/eprint/497

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