Uma, H and Selvaraj, P and Reetha, A M and Xavier, T and Prabhakar, R and Narayanan, P R
(1999)
Lymphocytotoxic antibodies & immunity in pulmonary tuberculosis.
Indian Journal of Medical Research, 109 (Jan).
pp. 5-10.
ISSN 0971-5916
Abstract
To understand whether the presence of cold reactive lymphocytotoxic antibodies (LCA) (reactive at
15°C) in the system has any effect on immunity to tuberculosis lymphocytotoxic antibodies to adherent
cells (enriched-B ceils) and non-adherent cells were studied in active-TB (n=42) and inactive-TB (cured)
patients (n=49) and healthy controls (n=32). The plasma samples of inactive-TB patients showed higher
percentage of positivity for lymphocytotoxic antibodies (36.7%) than the active-TB patients (21.4%) and
control subjects (18.8%). No significant difference on antibody and lymphocyte response against
Mycobacterium tuberculosis culture filtrate antigens was observed between LCA positive and LCA
negative active-TB patients and normal healthy controls. Further, determinationof HLA-DR phenotype
of the patients and control subjects showed that individuals positive for lymphocytotoxic antibodies
were more among HLA-DR2 positive and DR7 positive active-TB patients and control subjects than
non-DR2 and non-DR7 subjects. The present study suggests that the cold reactive lymphocytotoxic
antibodies may be against B-lymphocytes and persistent for a longer time. HLA-DR2 and -DR7 may be
associated with the occurrence of LCA activity. Further, the presence of LCA has no immunoregulatory
role on immunity to tuberculosis.
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