Lymphocytotoxic antibodies & immunity in pulmonary tuberculosis

Uma, H and Selvaraj, P and Reetha, A M and Xavier, T and Prabhakar, R and Narayanan, P R (1999) Lymphocytotoxic antibodies & immunity in pulmonary tuberculosis. Indian Journal of Medical Research, 109 (Jan). pp. 5-10. ISSN 0971-5916

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Abstract

To understand whether the presence of cold reactive lymphocytotoxic antibodies (LCA) (reactive at 15°C) in the system has any effect on immunity to tuberculosis lymphocytotoxic antibodies to adherent cells (enriched-B ceils) and non-adherent cells were studied in active-TB (n=42) and inactive-TB (cured) patients (n=49) and healthy controls (n=32). The plasma samples of inactive-TB patients showed higher percentage of positivity for lymphocytotoxic antibodies (36.7%) than the active-TB patients (21.4%) and control subjects (18.8%). No significant difference on antibody and lymphocyte response against Mycobacterium tuberculosis culture filtrate antigens was observed between LCA positive and LCA negative active-TB patients and normal healthy controls. Further, determinationof HLA-DR phenotype of the patients and control subjects showed that individuals positive for lymphocytotoxic antibodies were more among HLA-DR2 positive and DR7 positive active-TB patients and control subjects than non-DR2 and non-DR7 subjects. The present study suggests that the cold reactive lymphocytotoxic antibodies may be against B-lymphocytes and persistent for a longer time. HLA-DR2 and -DR7 may be associated with the occurrence of LCA activity. Further, the presence of LCA has no immunoregulatory role on immunity to tuberculosis.

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