Survelliance of drug resistance in tuberculosis in the state of Tamil Nadu

Paramasivan, C N and Bhaskaran, K and Venkataraman, P and Chandrasekaran, V and Narayanan, P R (2000) Survelliance of drug resistance in tuberculosis in the state of Tamil Nadu. Indian Journal of Tuberculosis, 47 (1). pp. 27-33. ISSN 0019-5705

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Summary: Surveillance of drug resistance was carried out at State level to obtain data which are standardised and comparable using guidelines prescribed by the WHO/IUATLD Working Group on Anti-tuberculosis Drug Resistance Surveillance. Objective: To determine the proportion of initial and acquired drug resistance in cases of pulmonary tuberculosis in Tamilnadu, in order to use the level of drug resistance as a performance indicator of the National Tuberculosis Programme. Methods: Two specimens of sputum from each of a total of 713 patients attending 145 participating centres all over the state were tested by smear and culture examination and drug susceptibility tests of Isoniazid, Rifampicin, Ethambutol and Streptomycin. Results: Out of 400 patients for whom drug susceptibility results were available, 384 (96%) had no history of previous anti-tuberculosis treatment. Of these, 312 (81%) were susceptible to all the drugs tested. Resistance to isoniazid was seen in 15.4% of patients and to Rifampicin in 4.4% including resistance to Isoniazid and Rifampicin in 3.4%. Conclusion: There has been a gradual increase in initial drug resistance over the years in this part of the country.

Item Type: Article
Uncontrolled Keywords: Pulmonary tuberculosis; Initial drug resistance; Acquired drug resistance
Subjects: Tuberculosis > Laboratory Research > Bacteriological
Divisions: Basic Science Research > Bacteriology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 05 Nov 2013 10:48
Last Modified: 10 Mar 2016 08:27

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