Role of Human Leucocyte Antigen (HLA) and Non-HLA genes in susceptibility or resistance to pulmonary tuberculosis

Selvaraj, P (2000) Role of Human Leucocyte Antigen (HLA) and Non-HLA genes in susceptibility or resistance to pulmonary tuberculosis. Indian Journal of Tuberculosis, 47 (3). pp. 133-138. ISSN 0019-5705

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Human beings live in an environment endemic to various diseases. Under such conditions, some individuals are susceptible to certain diseases while most are resistant to those diseases. This raises many questions. One such question is whether the person who is susceptible is genetically different from the person who is resistant to the disease? Similarly, in a family, one of the parents may be affected with a particular disease (e.g. diabetes); among the children born to the parents, if one child (younger one) develops the disease and the other child (elder one) does not, the question arises why did the younger one develop the disease and the elder did not, when both of them were living together with the affected parent. This raises the possibility of the disease being inherited from parents. If genetic factors play a major role in disease susceptibility or resistance, in what way are they associated with the disease development? Do they control the immune response to an antigen and/or pathogen? Do they play a role in the immune mechanism of susceptibility or resistance to disease? This article gives an account of disease susceptibility or resistance in pulmonary tuberculosis in the context of the host genetic factors, i.e. HLA (Human Leucocyte Antigens) and non- HLA genes and their gene products.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 05 Nov 2013 11:00
Last Modified: 10 Mar 2016 08:28

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