Risk of development of tuberculosis in HIV-infected patients

Swaminathan, S and Ramachandran, R and Baskaran, G and Paramasivan, C N and Ramanathan, U and Venkatesan, P and Prabhakar, R and Datta, M (2000) Risk of development of tuberculosis in HIV-infected patients. International Journal of Tuberculosis and Lung Disease, 4 (9). pp. 839-844. ISSN Print: 1027-3719; Online: 1815-7920

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OBJECTIVE: To estimate the rate of development of active tuberculosis (TB) in a cohort of human immunodeficiency virus (HIV) positive patients, and to identify the characteristics of these patients. DESIGN: A total of 175 HIV-positive individuals were recruited from clinics for sexually transmitted diseases and followed up for 31 ± 6.8 months. Clinical examination, chest X-ray, sputum smear for acid-fast bacilli and culture for mycobacteria and HIV serology were performed at the time of registration and repeated periodically. RESULTS: Seventeen patients had TB at intake and another 24 developed TB during follow-up, giving a breakdown rate of 6.9/100 person-years (p-y) (95% confidence interval [CI] 4.1-9.6). The attack rates were similar in tuberculin positive (7.1/100 p-y, 95%CI 3.4– 10.8) and negative (6.7/100 p-y, 95%CI 2.6–10.8) patients. There was a trend towards higher mortality in patients who developed TB (10.5/100 p-y, 95%CI 4.8– 15.2) compared to those who did not (6.1/100 p-y, 95%CI 3.2–8.8). CONCLUSIONS: The results of this study provide information regarding the high risk of development of active tuberculosis and its associated mortality in HIV-infected persons. The risk of developing TB appears to be equally high in tuberculin positive and negative individuals, suggesting that new infections could play a major role in this susceptible population.

Item Type: Article
Uncontrolled Keywords: HIV; tuberculosis; tuberculin reaction; mortality
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 05 Nov 2013 11:24
Last Modified: 10 Mar 2016 08:33
URI: http://eprints.nirt.res.in/id/eprint/523

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