Selvaraj, P and Kannapiran, M and Mathan Kurian, Sunil and Narayanan, P R
(2001)
Effect of plasma lysozyme on live
Mycobacterium tuberculosis.
Current Science, 81 (2).
pp. 201-203.
ISSN 0011-3891
Abstract
The role of plasma lysozyme of normal healthy subjects
(NHS, n = 12) and active pulmonary tuberculosis
(ATB) patients (n = 15) on the innate immune
mechanism was studied by the binding activity of
lysozyme on live Mycobacterium tuberculosis. Plasma
samples of NHS and ATB patients treated with live
M. tuberculosis for 4 h and 24 h time points showed a
significant decrease in the plasma lysozyme level
when compared to the untreated samples (4 h,
P < 0.001; 24 h, P < 0.001). Pretreatment of live M.
tuberculosis with plasma of NHS and ATB patients
showed a trend in the reduction of viability of live M.
tuberculosis. Moreover, M. tuberculosis pretreated
plasma of NHS showed a trend towards an increased
spontaneous as well as antigen-induced lymphocyte
response when compared to ATB plasma. The enzymatic
action of the lysozyme and other enzymes on
the cell wall may induce M. tuberculosis to release
some antigenic components which may be immunogenic
and induce lymphocyte proliferation. The present
study suggests that lysozyme and other enzymes
may play an important role in the first line defence,
i.e. the innate immunity, against M. tuberculosis infection.
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