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Immune response to Mycobacterium tuberculosis culture filtrate antigen in cured spinal tuberculosis patients and their spouses

Kurian, SunilMathan and Selvaraj, P and Reetha, A M and Charles, Niruparani and Mathan, Anila Anna and Narayanan, P R (2001) Immune response to Mycobacterium tuberculosis culture filtrate antigen in cured spinal tuberculosis patients and their spouses. Indian Journal of Tuberculosis, 48 (1). pp. 3-7. ISSN 0019-5705

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Abstract

Humoral and cell mediated immune responses were studied in cured spinal tuberculosis patients and their spouses to understand immunit to tuberculosis in cured patients. Antibody litre and immune complex levels were measured and lymphocyte response to Mycobaclerinm tuberculosis culture filtrate antigen was observed in cured spinal tuberculosis patients ( n = 3 0 ) and their spouses (n =27). A trend towards increased antibody litre was seen in cured patients as compared to their spouses. Significantly increased circulating immune complex levels, as measured by PEG OD280 (polyethylene glycol optical density 280) were seen in the contacts compared to cured patients. And a trend towards increased lymphocyte response to Mtuberculosis culture filtrate antigen was seen with different antigen concentrations (0.1,1 and 10 μg /ml). Moreover, the effect of active-pulmonary-Tuberculosis (AT B) plasma taken from 1ILA-DR2 positive and DR2 negative patients on lymphocyte response of the cured patients showed no dramatic immunomodulatory effect in the lymphocyte response when treated with DR2 positive or DR2 negative plasma. The study suggests that the memory response lo Mtuberculosis is well maintained even after 10-15 years of treatment.

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Item Type: Article
Uncontrolled Keywords: Antibody litre; immune complex; lymphocyte response; spinal tuberculosis
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 07 Nov 2013 06:48
Last Modified: 10 Mar 2016 07:05
URI: http://eprints.nirt.res.in/id/eprint/540

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