Cytogenetic studies on spray painters in south India

Gajalakshmi, P and Balasundaram, A and Venkatesan, P and Santhiya, S T and Ramesh, A (2002) Cytogenetic studies on spray painters in south India. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 514 (1). pp. 1-6. ISSN 1383-5718

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Studies on the frequencies of chromosomal aberrations were carried out on 104 spray painters working in automobile body reconditioning, steel furniture making and refrigerator repainting workshops in the metro city, Chennai, of south India. Randomly selected 50 male subjects not connected with this occupation were included as controls in the study. Chromosomal analysis was carried out in 48 h lymphocyte (short duration) cultures representing the first mitotic division, on a subset of samples consisting of 50 spray painters, 20 controls and 72 h (longer duration) cultures representing the second cell division, on all subjects. Baseline frequency of chromosomal aberrations was significantly higher among painters as compared to matched controls. Smoking and alcoholism as modulating factors had no added effect on the frequency of aberrant metaphases. Stepwise multiple linear regression analysis indicated that duration of service and age were significant factors that influence the frequency of chromosomal aberrations observed. © 2002 Elsevier Science B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Spray painters; Chromosome analysis; Genotoxicity; Occupational exposure; Cytogenetic effects
Subjects: Tuberculosis > Epidemiological Research
Divisions: Epidemiology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 08 Nov 2013 05:55
Last Modified: 10 Mar 2016 04:31

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