715. Chandra G, et al. BamH1 polymorphism of Human Cytochrome P450 gene, CYP2D6, in quiescent and relpse patients of pulmonary tuberculosis

Chandra, G and Selvaraj, P and Reetha, A M and Narayanan, P R (2003) 715. Chandra G, et al. BamH1 polymorphism of Human Cytochrome P450 gene, CYP2D6, in quiescent and relpse patients of pulmonary tuberculosis. Biomedicine, 23 (1&2). pp. 27-32. ISSN 0970-2067

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Abstract

BamH l polymorphism of the human cytochrome P450 gene, CYP2D6, which encodes drug metabolizing enzyme, was studied to find out whether variant genotypes of this gene are associated with the susceptibility or resistance to bacteriological relapse of pulmonary tuberculosis after stopping treatment with short-course chemotherapy of 6-8 months duration. The study was carried out in control subjects (n=158), patients with pulmonary tuberculosis (n=154), patients with bacteriological relapse (n=50) and quiescent patients (n=50). No difference in the frequency of variant genotypes of BarnH l polymorphism of CYP2D6 gene was observed between pulmonary TB patients and control subjects. A trend towards an increased frequency of 22 genotype (homozygous for infrequent allele 2) was observed in bacteriological relapse patients than quiescent patients (odds ratio, OR: 2). Similar increase was observed in male relapse patients than male quiescent patients (OR: 2.2). The present study suggests that 22 genotype of BamH l polymorphism of CYP2D6 of human cytochrome P450 gene either alone or in combination with closely linked genes may be associated with bacteriological relapse especially in male patients of pulmonary tuberculosis.

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