Chandra, G and Selvaraj, P and Reetha, A M and Narayanan, P R
(2003)
715. Chandra G, et al. BamH1 polymorphism of Human Cytochrome P450 gene, CYP2D6, in quiescent and relpse patients of pulmonary tuberculosis.
Biomedicine, 23 (1&2).
pp. 27-32.
ISSN 0970-2067
Abstract
BamH l polymorphism of the human cytochrome P450 gene, CYP2D6,
which encodes drug metabolizing enzyme, was studied to find out
whether variant genotypes of this gene are associated with the
susceptibility or resistance to bacteriological relapse of pulmonary
tuberculosis after stopping treatment with short-course
chemotherapy of 6-8 months duration. The study was carried out in
control subjects (n=158), patients with pulmonary tuberculosis
(n=154), patients with bacteriological relapse (n=50) and quiescent
patients (n=50). No difference in the frequency of variant genotypes
of BarnH l polymorphism of CYP2D6 gene was observed between
pulmonary TB patients and control subjects. A trend towards an
increased frequency of 22 genotype (homozygous for infrequent
allele 2) was observed in bacteriological relapse patients than
quiescent patients (odds ratio, OR: 2). Similar increase was
observed in male relapse patients than male quiescent patients (OR:
2.2). The present study suggests that 22 genotype of BamH l
polymorphism of CYP2D6 of human cytochrome P450 gene either
alone or in combination with closely linked genes may be associated
with bacteriological relapse especially in male patients of pulmonary
tuberculosis.
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