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Virulence in the guinea-pig and susceptibility to hydrogen paroxide of isoniazid-sensitive tubercle bacilli from South Indian patients

Narayanan Nair, C and Mackay-Scollay, E M and Ramachandran, K and Selkon, J B and Tripathy, S P and Mitchison, D A and Dickinson, Jean M (1964) Virulence in the guinea-pig and susceptibility to hydrogen paroxide of isoniazid-sensitive tubercle bacilli from South Indian patients. Tubercle, 45 (4). pp. 345-353. ISSN 0041-3879

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Abstract

Tests for virulence in the guinea-pig and for susceptibility to the bactericidal activity of hydrogen peroxide were done on cultures of isoniazid-sensitive tubercle bacilli obtained from 220 South Indian patients with pulmonary tuberculosis before the start of antituberculosis chemotherapy. An association was found between the virulence of the cultures and the proportion of their organisms surviving exposure to 0.02% peroxide; 10% or more organisms survived in 11 % of 152 cultures of low virulence and in 57 % of 68 cultures of high virulence. There was some suggestion that the cultures could be divided into two groups, the larger, containing about 74% of the cultures, having low virulence and high peroxide susceptibility and the smaller having high virulence and low peroxide susceptibility.

NIRT Creators:
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Item Type: Article
Subjects: Tuberculosis > Operational Research
Divisions: Epideimology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 17 Jul 2013 07:03
Last Modified: 08 Mar 2016 04:45
URI: http://eprints.nirt.res.in/id/eprint/61

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