Selvaraj, P and Chandra, G and Kurian, Sunil Mathan and Reetha, A M and Narayanan, P R
(2003)
Association of vitamin D receptor gene
variants of BsmI, ApaI and FokI
polymorphisms with susceptibility or
resistance to pulmonary tuberculosis.
Current Science, 84 (12).
pp. 1564-1563.
ISSN 0011-3891
Abstract
Vitamin D receptor (VDR) gene polymorphism was
studied to find out whether the variants of this gene
are associated with susceptibility or resistance to
pulmonary tuberculosis (PTB) and bacteriological
relapse of tuberculosis. BsmI, ApaI and FokI polymorphisms
of VDR gene were studied in PTB patients
(n = 120), patient contacts (spouses of the patients;
n = 80), bacteriological relapse patients (n = 48) and
quiescent patients (n = 48). Significant increase of Bb
genotype (heterozygote carrier) of BsmI polymorphism
(P = 0.028) and FF genotype (homozygotes of
common allele F) of FokI polymorphism (P = 0.034)
were observed in male PTB patients than male contacts.
The BB genotype (homozygote of common allele
B) of BsmI polymorphism and AA genotype (homozygote
of common allele A) of ApaI polymorphism
were increased in male contacts than male PTB
patients (BB: P = 0.018; AA: P = 0.04). No significant
differences were found among female patients and
female contacts. In bacteriological relapse cases of PTB, a decreased frequency of AA genotype (P =
0.015) and an increased frequency of Aa genotype
(P = 0.024) were observed in bacteriological relapse
patients than quiescent patients of PTB. The present
study suggests that Bb genotype of BsmI polymorphism
and FF genotype of FokI polymorphism of
VDR gene may be associated with the susceptibility to
tuberculosis in males. The BB and AA genotypes may
be associated with resistance to PTB in males. The
genotype Aa may be associated with bacteriological
relapse and AA may be associated with protection
against bacteriological relapse.
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