Swaminathan, S and Kuppurao, K V and Somu, N and Vijayan, V K
(2003)
Reduced Exercise Capacity in Non-Cystic Fibrosis
Bronchiectasis.
Indian Journal of Pediatrics, 70 (7).
pp. 553-556.
ISSN Print: 0019-5456; Online: 0973-7693
Abstract
Objective : Bronchiectasis not due to cystic fibrosis is usually a consequence of severe bacterial or tuberculous
infection of the lungs, which is commonly seen in children in developing countries. Our aim was to study its functional sequelae
and affect on work capacity in children. Methods : Seventeen children (7-17 years of age) with clinical and radiological
evidence of bronchiectasis of one or both lungs were studied at the Cardiopulmonaly Unit of the Tuberculosis Research Centre.
Pulmonary function tests including spirometry and lung volume measurements were performed. Incremental exercise stress
test was done on a treadmill, and ventilatory and cardiac parameters we monitored. Control values were taken from a previous
study. Results : Children with bronchiectasis had lower forced vital capacity (FVC) (1.1 + 0.4 L versus 1.5 + 0.4 L, p=0.003)
and FEV1 (0.95 ± 0.2 L versus 1.4 ± 0.3 L, p<0.002) compared to age- and sex-matched healthy controls. The patient group
had significantly higher residual lung volumes (0.7 ± 0.3 L versus 0.4 + 0.1 L, p<0.02). At maximal exercise, they had lower
aerobic capacity (28 ± 6 ml/min/kg versus 38 5 ml/min/kg, p<0.0001) and maximal ventilation (24 ± 8 L/min versus 39 ± 10
L/min, p<0.001). At maximal exercise, while none of the controls desaturated, oxygen saturation fell below 88% in eight of 17
patients. conclusion ;The findings show that children and adolescents with non-cystic fibrosis bronchiectasis have abnormal
pulmonary function and reduced exercise capacity. This is likely to interfere with their lie as well as future work capacity. Efforts
should be made to minimize lung damage in childhood by ensuring early diagnosis and instituting appropriate treatment of
respiratory infections.
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