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Correlates of protective immune response in tuberculous pleuritis

Jalapathy, Kripa V and Prabha, C and Das, Sulochana D (2004) Correlates of protective immune response in tuberculous pleuritis. FEMS Immunology and Medical Microbiology, 40 (2). pp. 139-145. ISSN Print: 0928-8244l; Online: 1574-695X

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Abstract

Tuberculous pleuritis (TB) provides a good model to study the correlates of protective immune response at the site of infection. To study the in vivo correlates of immunity, cell subset profile and cytokine assay in plasma (BL) and pleural fluid (PF) of 82 patients were done. Lymphocyte proliferation and cytokine response to mycobacterial antigens were measured in 32 subjects to understand the in vitro correlates. Increase in CD4þ cells and CD4þ/CD8þ ratio with selective concentration of interferon (IFN)-Q, tumour necrosis factor (TNF)-K and interleukin (IL)-12 in PF suggests that the CD4þ population may be of TH1 type. We observed an accelerated lymphoproliferative response to purified protein derivative (PPD) and heat killed Mycobacterium tuberculosis (MTB) in PF cells of both TB and non-TB (NTB) subjects. Interestingly, in in vitro studies, IL-4 levels together with IFN-Q were significantly increased in the supernatants of PF mononuclear cells (PFMC) of TB patients and showed a shift in immune response towards TH0/TH2 type. PPD and MTB antigens induced an enhanced proliferation of PFMC and also increased in vitro IL-4 response together with apoptosis, thus eliciting a dual response.

Item Type: Article
Uncontrolled Keywords: Tuberculous pleuritis ; Cell subset; TH1 cytokine; TH2 cytokine; Lymphocyte; Proliferation
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 20 Nov 2013 09:15
Last Modified: 09 Mar 2016 10:19
URI: http://eprints.nirt.res.in/id/eprint/651

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