Paramasivan, C N and Venkataraman, P
(2004)
Drug resistance in tuberculosis in India.
Indian Journal of Medical Research, 120 (Oct).
pp. 377-386.
ISSN 0971-5916
Abstract
The current global concern in the treatment of tuberculosis (TB) is the emergence of resistance
to the two most potent drugs viz., isoniazid and rifampicin. The level of initial drug resistance
is an epidemiological indicator to assess the success of the TB control programme. Though
drug resistance in TB has frequently been reported from India, most of the available information
is localized, sketchy or incomplete. A review of the few authentic reports indicates that there is
no clear evidence of an increase in the prevalence of initial resistance over the years. However,
a much higher prevalence of acquired resistance has been reported from several regions, though
based on smaller numbers of patients. A strong TB control programme and continuous
surveillance studies employing standardized methodology and rigorous quality control
measures will serve as useful parameters in the evaluation of current treatment policies as well
as the management of multidrug resistant (MDR) TB cases.
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