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Influence of Active Tuberculosis on Chemokine and Chemokine Receptor Expression in HIV-Infected Persons

Hanna, L E and Bose, J C and Nayak, Kaustuv and Subramanyam, Sudha and Swaminathan, Soumya (2005) Influence of Active Tuberculosis on Chemokine and Chemokine Receptor Expression in HIV-Infected Persons. AIDS Research and Human Retroviruses, 21 (12). pp. 997-1002. ISSN Print: 0889-2229; Online: 1931-8405

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Tuberculosis (TB) is the major opportunistic infection of HIV-1-infected patients in developing countries. Concurrent infection with TB results in immune cells having enhanced susceptibility to HIV-1 infection, which facilitates entry and replication of the virus. Cumulative data from earlier studies indicate that TB provides a milieu of continuous cellular activation and irregularities in cytokine and chemokine circuits that favor viral replication and disease progression. To better understand the interaction of the host with HIV-1 during active tuberculosis, we investigated in vivo expression of the HIV-1 coreceptors, CCR5 and CXCR4, and circulating levels of the inhibitory �-chemokines, macrophage inflammatory protein-1-� (MIP-1�), macrophage inflammatory protein-1-� (MIP-1�), and regulated upon activation T cell expressed and secreted (RANTES), in HIV-positive individuals with and without active pulmonary tuberculosis. We found a significant decrease from normal in the fraction of CD4� T cells expressing CCR5 and CXCR4 in individuals infected with HIV. However, CCR5 and CXCR4 expression did not differ significantly between HIV patients with and without tuberculosis. Higher amounts of MIP-1�, MIP-1�, and RANTES were detected in plasma of HIV-1-positive individuals, particularly those with dual infection, although the increase was not found to be statistically significant.

Item Type: Article
Subjects: Tuberculosis > HIV - Basic Science
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 27 Nov 2013 08:03
Last Modified: 09 Mar 2016 07:05

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