Vijayalakshmi, K and Thangaraj, K and Rajender, S and Vettriselvi, V and Venkatesan, P and Shroff, S and Vishwanathan, K N and Paul, S F D
(2006)
GGN repeat length and GGN/CAG haplotype variations in the androgen receptor gene and prostrate cancer risk in south Indian men.
Journal of Human Genetics, 51 (11).
pp. 998-1005.
ISSN Print: 1434-5161; Online: 1435-232X
Abstract
The ethnic variation in the GGN and CAG
microsatellites of the androgen receptor (AR) gene
suggests their role in the substantial racial difference in
prostate cancer risk. Hence, we performed a casecontrol
study to assess whether GGN repeats independently
or in combination with CAG repeats were
associated with prostate cancer risk in South Indian
men. The repeat lengths of the AR gene determined by
Gene scan analysis, revealed that men with GGN repeats
£21 had no significant risk compared to those
with >21 repeats (OR 0.91 at 95% CI-0.52–1.58).
However, when CAG repeats of our earlier study was
combined with the GGN repeat data, the cases
exhibited significantly higher frequency of the haplotypes
CAG £19/GGN £21 (OR-5.2 at 95% CI-2.17–
12.48, P < 0.001) and CAG £19/GGN > 21(OR-6.9 at
95%CI-2.85–17.01, P < 0.001) compared to the controls.
No significant association was observed between
GGN repeats and prostate-specific antigen levels and
the age at diagnosis. Although a trend of short GGN
repeats length in high-grade was observed, it was not
significant (P = 0.09). Overall, our data reveals that
specific GGN/CAG haplotypes (CAG £19/GGN £21
and CAG £19/GGN > 21) of AR gene increase the
risk of prostate cancer and thus could serve as susceptibility
marker for prostate cancer in South Indian
men.
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