Joseph, Pauline and Chandrasekaran, V and Thomas, A and Gopi, P G and Rajeswari, R and Balasubramanian, R and Subramani, R and Selvakumar, N and Santha, T
(2006)
Influence of drug susceptibility on treatment outcome and susceptibility profile of 'failures' to category II regimen.
Indian Journal of Tuberculosis, 53 (4).
pp. 141-148.
ISSN 0019-5705
Abstract
Objective: To assess the influence of drug resistance on treatment outcome among patients treated with Category-II regimen
and document drug susceptibility pattern of “Failures” to this regimen.
Design: A retrospective analysis of patients registered from May 1999 through December 2004.
Results: Treatment success was 42% among 572 patients and was similar among patients with fully susceptible or resistant but
non-MDR organisms (41% of 254 and 40% of 128 patients, respectively). Among 49 MDR-TB patients, 27% had successful
treatment outcome. The failure rates among patients with fully susceptible, resistant but non-MDR and MDR bacilli, were 6%,
12% and 27% respectively. Default was significantly higher among males (53% vs. 34%: p<0.01) smokers (57% vs. 36%: p
<0.001), alcoholics (58% vs. 39%: p <0.001) and patients with higher initial smear grading (2+ or 3+, 56% vs. scanty or 1+,
44%: p <0.01). DST results were available for 60% (31 of 52) of failures and 10 had MDR-TB.
Conclusion: The low success rate to the re-treatment regimen was mainly due to non-compliance. Failure was observed among
9% of patients and MDR-TB was 32% among Category II failures. The currently recommended Category II regimen appears
to be adequate for majority of re-treatment cases.
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