Promoting Open Access to Exploring the Research

Influence of drug susceptibility on treatment outcome and susceptibility profile of 'failures' to category II regimen

Joseph, Pauline and Chandrasekaran, V and Thomas, A and Gopi, P G and Rajeswari, R and Balasubramanian, R and Subramani, R and Selvakumar, N and Santha, T (2006) Influence of drug susceptibility on treatment outcome and susceptibility profile of 'failures' to category II regimen. Indian Journal of Tuberculosis, 53 (4). pp. 141-148. ISSN 0019-5705

[img]
Preview
PDF
200639.pdf - Published Version

Download (41kB)
Official URL: http://medind.nic.in/ibr/t06/i3/ibrt06i3p141.pdf

Abstract

Objective: To assess the influence of drug resistance on treatment outcome among patients treated with Category-II regimen and document drug susceptibility pattern of “Failures” to this regimen. Design: A retrospective analysis of patients registered from May 1999 through December 2004. Results: Treatment success was 42% among 572 patients and was similar among patients with fully susceptible or resistant but non-MDR organisms (41% of 254 and 40% of 128 patients, respectively). Among 49 MDR-TB patients, 27% had successful treatment outcome. The failure rates among patients with fully susceptible, resistant but non-MDR and MDR bacilli, were 6%, 12% and 27% respectively. Default was significantly higher among males (53% vs. 34%: p<0.01) smokers (57% vs. 36%: p <0.001), alcoholics (58% vs. 39%: p <0.001) and patients with higher initial smear grading (2+ or 3+, 56% vs. scanty or 1+, 44%: p <0.01). DST results were available for 60% (31 of 52) of failures and 10 had MDR-TB. Conclusion: The low success rate to the re-treatment regimen was mainly due to non-compliance. Failure was observed among 9% of patients and MDR-TB was 32% among Category II failures. The currently recommended Category II regimen appears to be adequate for majority of re-treatment cases.

NIRT Creators:
NIRT CreatorsEmail
Item Type: Article
Uncontrolled Keywords: Treatment outcome, Category II regimen, failure, RNTCP, MDR-TB
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 12 Dec 2013 08:46
Last Modified: 09 Mar 2016 06:11
URI: http://eprints.nirt.res.in/id/eprint/766

Actions (login required)

View Item View Item