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Initial drug susceptibility profile of M. tuberculosis among patients under TB programme in South India

Santha, T and Thomas, A and Chandrasekaran, V and Selvakumar, N and Gopi, P G and Subramani, R and Rajeswari, R and Rani, B and Paramasivan, C N and Perumal, M and Wares, F and Narayanan, P R (2006) Initial drug susceptibility profile of M. tuberculosis among patients under TB programme in South India. International Journal of Tuberculosis and Lung Disease, 10 (1). pp. 52-57. ISSN Print: 1027-3719; Online: 1815-7920

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SETTING: Pulmonary tuberculosis (PTB) patients enrolled for treatment at government health facilities in a sub-district of Thiruvallur district, Tamil Nadu, India. OBJECTIVES: To determine the drug susceptibility profile among PTB patients admitted to treatment according to the Revised National Tuberculosis Control Programme (RNTCP). METHODOLOGY: From May 1999 to December 2003, two additional sputum samples were collected from all patients at the start of anti-tuberculosis treatment under DOTS and were transported to a central laboratory for Mycobacterium tuberculosis culture and drug susceptibility testing (DST). RESULTS: DST results were available for 1603 new sputum smear-positive patients; 85% of patients had organisms fully susceptible to streptomycin (S), isoniazid (H) and rifampicin (R), 10.4% any resistance to H and 1.7% to HR. Of 443 patients with history of previous anti-tuberculosis treatment, 59% had organisms susceptible to S, H and R, 37% had any resistance to H and 11.7% to HR. CONCLUSION: The DST profile showed that the vast majority of patients have drug-susceptible organisms, and that currently recommended regimens under the RNTCP would be effective in the treatment of TB.

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Item Type: Article
Uncontrolled Keywords: pulmonary tuberculosis; drug susceptibility; DOTS; south India
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 13 Dec 2013 08:21
Last Modified: 09 Mar 2016 06:23

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