Selvaraj, P and Prabhu Anand, S and Jawahar, M S and Chandra, G and Banu Rekha, V V and Narayanan, P R
(2006)
Promoter polymorphism of IL-8 gene
and IL-8 production in pulmonary
tuberculosis.
Current Science, 90 (7).
pp. 952-954.
ISSN 0011-3891
Abstract
Interleukin-8 (IL-8) is a chemokine which functions as
a potent chemo attractant for the recruitment of leucocytes
to the inflammatory sites. A polymorphism in
position –251 in the promoter region of the IL-8 gene
has been shown to be associated with altered IL-8 production.
IL-8-251A promoter polymorphism was studied
in 127 pulmonary tuberculosis (PTB) patients and
124 normal healthy subjects (NHS). IL-8 gene variants
were correlated with IL-8 levels from peripheral blood
mononuclear cells stimulated with phytohaemagglutinin,
culture filtrate antigen (CFA) of Mycobacterium
tuberculosis and live M. tuberculosis. No difference
was observed in the variant genotype frequencies of
IL-8 gene and IL-8 levels between NHS and PTB patients.
NHS positive for TT genotype showed a higher spontaneous
IL-8 production than AA genotype (P = 0.05).
Similarly, PTB patients with TT genotype showed significantly
higher IL-8 production to CFA (P = 0.009)
and live M. tuberculosis (P = 0.022), compared to patients
with AA genotype. The study suggests that the
variant genotypes of –251 promoter polymorphism of
the IL-8 gene are not associated with susceptibility to
PTB. Probably, TT genotype may be associated with
higher IL-8 production and increased leucocyte accumulation
and inflammation at the site of M. tuberculosis
infection.
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