Susceptibility of Mycobacterium tuberculosis Strains to Gatifl oxacin and Moxifl oxacin by Different Methods

Somasundaram, Sulochana and Paramasivan, C N (2006) Susceptibility of Mycobacterium tuberculosis Strains to Gatifl oxacin and Moxifl oxacin by Different Methods. Chemotherapy, 52 (4). pp. 190-195. ISSN Print: 0009-3157, Online: 1421-9794

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Abstract

Background: Considering the potentials of gatifl oxacin and moxifl oxacin in the treatment of tuberculosis, the present study was aimed to defi ne resistance to both these drugs. Methods: Fifty Mycobacterium tuberculosis isolates, consisting of 30 ofl oxacin-susceptible and 20 ofl oxacin-resistant strains, were tested for their susceptibility to gatifl oxacin and moxifl oxacin using different susceptibility testing methods, namely the absolute concentration method on Lowenstein-Jensen medium (LJ), the proportion susceptibility testing method (PST) on LJ and 7H11 agar media, and the BACTEC radiometric method. Result: The minimal inhibitory concentration (MIC) of gatifl oxacin and moxifl oxacin was 1 � g/ml by the absolute concentration method on LJ. In the PST method on LJ and 7H11, using a criterion of 6 1% growth as resistant, there was 100% agreement with the absolute concentration method at a concentration of 0.5 � g/ ml for gatifl oxacin, and 96% agreement with the BACTEC method at a concentration of 0.25 � g/ml. For moxifl oxacin, results by the PST method showed 96% agreement with the absolute concentration method on LJ at a concentration of 1 � g/ml and 92% agreement at a concentration of 0.5 � g/ml for both the absolute concentration method on 7H11 and the BACTEC method. Conclusions: The MICs of gatifl oxacin and moxifl oxacin were much lower than the MICs of other quinolones like ofl oxacin and ciprofl oxacin. Additionally, these two drugs have shown a low mean MIC and low concentration as a definition of resistance, which might help in treating the patients with low levels of quinolone resistance.

Item Type:	Article
Uncontrolled Keywords:	Mycobacterium tuberculosis, � Gatifloxacin, � Moxifl oxacin
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	19 Dec 2013 10:45
Last Modified:	09 Mar 2016 06:29
URI:	http://eprints.nirt.res.in/id/eprint/783

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