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Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India

Alagarasu, K and Selvaraj, P and Swaminathan, Soumya and Raghavan, S and Narendran, G and Narayanan, P R (2007) Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India. Tuberculosis, 87 (6). pp. 535-543. ISSN Print:1472-9792; Online: 1873-281X

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Mannose binding lectin (MBL) plays an important role in innate immunity. Plasma MBL levels and MBL2 gene polymorphisms were studied in HIV-1 infected patients without tuberculosis (HIV+TB�) (n ¼ 151) and with tuberculosis (HIV+TB+) (n ¼ 109), HIV negative tuberculosis patients (HIV�TB+) (n ¼ 148) and healthy controls (n ¼ 146) by ELISA and genotyping by polymerase chain reaction based methods. MBL levels were significantly increased among HIV�TB+ and HIV+TB+ patients than controls and HIV+TB� patients (Po0.05). A significantly increased frequency of OO genotype of structural polymorphism and YY genotype of �221Y/X was observed among HIV�TB+ patients than controls. In HIV+TB+ patients, a significantly increased frequency of YA/YA diplotype (associated with very high MBL levels) was observed compared to controls (P ¼ 0.03). In HIV+TB+ patients, a significantly decreased frequency of medium MBL expression diplotypes (XA/XA and YA/YO) were noticed compared to HIV+TB� and healthy controls. The results suggest that YA/YA diplotype associated with very high MBL levels may predispose HIV-infected patients to tuberculosis while O/O genotype associated with very low MBL levels may be associated with susceptibility to tuberculosis in HIV uninfected individuals. Medium MBL expression diplotypes might protect against development of TB in HIV-infected patients.

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Item Type: Article
Uncontrolled Keywords: MBL; HIV; HIV–TB; Tuberculosis; Gene polymorphisms
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 31 Dec 2013 09:43
Last Modified: 09 Mar 2016 04:30

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