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Sodium nitroprusside test for the detection of isoniazid and acetylisoniazid in urine

Nageswara Rao, K V and Eidus, L and Jacob, C V and Radhakrishna, S and Tripathy, S P (1967) Sodium nitroprusside test for the detection of isoniazid and acetylisoniazid in urine. Tubercle, 48 (1). pp. 45-50. ISSN 0041-3879

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Abstract

detecting presence of isoniazid and acetylisoniazid in urine. The test result is positive in all urine specimens collected at eight hours after administration of 200 mg. or 400 mg. of isoniazid, and in about 90 % of the specimens collected between 10 and 12 hours. The test appears to be slightly more sensitive than the paper test of Gangadharam, Nair & Subbaiah (1962) for free isoniazid, but is appreciably less sensitive than the acetylisoniazid test of Eidus & Hamilton (1964). It does not suffer any interference from streptomycin, PAS and thiacetazone (thioacetazone) at conventional dosages used in clinical practice, but is affected by pyrazinamide, cycloserine and ethionamide.

NIRT Creators:
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Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Biochemical,Clinical and Pharmacological
Divisions: Basic Science Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 18 Jul 2013 10:07
Last Modified: 08 Mar 2016 06:20
URI: http://eprints.nirt.res.in/id/eprint/81

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