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Cycloserine plus ethionamide in the treatment of patients excreting isoniazid-resistant tubercle bacilli following previous chemotherapy

Ramakrishnan, C V and Devadatta, S and Evans, C and Kamat, S R and Menon, N K and Radhakrishna, S and Rajagopalan , S and Stott, H and Tripathy, S P and Velu, S (1967) Cycloserine plus ethionamide in the treatment of patients excreting isoniazid-resistant tubercle bacilli following previous chemotherapy. Tubercle, 48 (2). pp. 114-127. ISSN 0041-3879

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Abstract

Fifty patients with chronic pulmonary tuberculosis and cultures resistant to isoniazid were treated with a daily regimen of ethionamide (500 mg.) plus cycloserine in an intended dose of 500 mg., but possibly less because of deterioration. Most of the patients had streptomycin- resistant cultures also. Forty-three had received two previous regimens of chemotherapy. During the year, 10 (20%) patients became un-cooperative and refused further treatment, and in two the regimen was stopped on account of drug toxicity. Of the remaining 38 patients, 58% had bacteriologically quiescent disease at one year, 65 % showed radiographic improvement and 61% had cavity closure or less cavitation than on admission. Major toxicity to ethionamide occurred in two patients and to cycloserine in two patients; minor side effects were reported by 18 patients.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research
Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 18 Jul 2013 10:20
Last Modified: 08 Mar 2016 06:20
URI: http://eprints.nirt.res.in/id/eprint/82

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