Fluorescence test for the detection of ethionamide metabolites in urine

Venkatesan, P and Eidus, L and Tripathy, S P and Velu, S (1967) Fluorescence test for the detection of ethionamide metabolites in urine. Tubercle, 48 (4). pp. 291-296. ISSN 0041-3879

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Abstract

A test for the detection of metabolites of ethionamide in urine is described. It is based on the observation that these metabolites fluoresce under the effect of ultra-violet light. In studies on volunteers and patients, the test showed positive results in 86 % of specimens collected at 1-3 hours after administering 0.5 g. of ethionamide, and in 100% of those collected at 4-18 hours following administration of the drug. The specimens collected at 24 and 48 hours showed positive results in 85 % and 38 %, respectively. The test is simple, specific and reproducible.

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