Radha, Gopalaswamy and Sujatha, Narayanan and Jacobs, W R and Av-Gay, Yossef
(2008)
Mycobacteriumsmegmatis bio¢lm formationand slidingmotility
are a¡ected by the serine/threonine protein kinase PknF.
FEMS Microbiology Letters, 278.
pp. 121-127.
ISSN Print: 0378-1097; Online: 1574-6968
Abstract
Eighteen ‘eukaryotic-like’ serine/threonine kinases are present in the Mycobacterium
smegmatis genome. One of them encoded by the ORF 3677 demonstrates high
similarity to the Mycobacterium tuberculosis protein kinase PknF. A merodiploid
strain was generated, which showed reduced growth associated with irregular cell
structure. The merodiploid strain displayed altered colony morphology, defective
slidingmotility and biofilm formation. These data indicate a role for PknF in biofilm
formation, possibly associated with alterations in glycopeptidolipid composition.
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