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Mycobacteriumsmegmatis bio¢lm formationand slidingmotility are a¡ected by the serine/threonine protein kinase PknF

Radha, Gopalaswamy and Sujatha, Narayanan and Jacobs, W R and Av-Gay, Yossef (2008) Mycobacteriumsmegmatis bio¢lm formationand slidingmotility are a¡ected by the serine/threonine protein kinase PknF. FEMS Microbiology Letters, 278. pp. 121-127. ISSN Print: 0378-1097; Online: 1574-6968

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Abstract

Eighteen ‘eukaryotic-like’ serine/threonine kinases are present in the Mycobacterium smegmatis genome. One of them encoded by the ORF 3677 demonstrates high similarity to the Mycobacterium tuberculosis protein kinase PknF. A merodiploid strain was generated, which showed reduced growth associated with irregular cell structure. The merodiploid strain displayed altered colony morphology, defective slidingmotility and biofilm formation. These data indicate a role for PknF in biofilm formation, possibly associated with alterations in glycopeptidolipid composition.

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Item Type: Article
Additional Information: DOI:10.1111/j.1574-6968.2007.00989.x
Uncontrolled Keywords: mycobacteria; serine/threonine kinase; GPLs; sliding motility; biofilm;cell morphology
Subjects: Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 19 May 2017 07:38
Last Modified: 19 May 2017 07:38
URI: http://eprints.nirt.res.in/id/eprint/856

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