Deterioration of cycloserine in the tropics

Nageswara Rao, K V and Eidus, L and Evans, C and Kailasam, S and Radhakrishna, S and Somasundaram, P R and Stott, H and Subbammal, S and Tripathy, S P (1968) Deterioration of cycloserine in the tropics. Bulletin of the World Health Organization, 39 (5). pp. 781-789. ISSN 00429686

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Gross deterioration of cycloserine during transit and storage in the tropics is reported from the Tuberculosis Chemotherapy Centre, Madras. Laboratory experiments suggest that high humidity, rather than high temperature, is the main cause of the deterioration. Further investigations undertaken at the Centre indicate that deterioration can be prevented by storing the drug in tightly closed glass bottles in an air-conditioned room (18°C) ; if such facilities are not available, and the drug has to be stored at ambient temperature and humidity, the use of air-tight polyethylene bottles will serve to delay the deterioration. The findings also suggest that, when cycloserine is dispensed to patients, individual doses should be heat-sealed in polyethylene strips and that not more than a week’s supply should be given at any one time. The authors discuss various measures that could be employed by manufacturers and by shipping and clearing agents to minimize the possibility of deterioration.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research
Divisions: Basic Science Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 18 Jul 2013 11:22
Last Modified: 08 Mar 2016 06:25

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