Ramakrishnan, C V and Janardhanam, B and Krishnamurthy, D V and Stott, H and Subbammal, S and Tripathy, S P
(1968)
Toxicity of Pyrazinamide, Administered Once
Weekly in High Dosage, in Tuberculous Patients.
Bulletin of the World Health Organization, 39 (5).
pp. 775-779.
ISSN 00429686
Abstract
The success of a twice-weekly regimen of streptomycin plus isoniazid, reported earlier
from the Tuberculosis Chemotherapy Centre, Madras, prompted an investigation at the
Centre of various once-weekly regimens of chemotherapy. In this context, a pilot study was
undertaken in 19 patients to assess the toxicity of high-dosage pyrazinamide (70 mg/kg of
body-weight), when administered once weekly, together with isoniazid (14 mg/kg of bodyweight)
and streptomycin (1 g), for at least 6 months. Serial estimations of SGOT and
SGPT activity, urine tests for urobilin and bilirubin and haematological investigations were
undertaken at frequent intervals. None of the patients showed any clinical evidence of
hepatotoxicity ; however, there was a slight and transient elevation in aminotransferase
activity, probably of a non-specific nature, at 2 weeks. These findings are encouraging for
the use of high-dosage pyrazinamide in once-weekly regimens of chemotherapy
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