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Serum zinc and albumin levels in pulmonary tuberculosis patients with and without HIV

Ramakrishnan, K and Shenbagarathai, R and Kavitha, K and Uma, A and Balasubramaniam, R and Thirumalaikolundu Subramanian, P (2008) Serum zinc and albumin levels in pulmonary tuberculosis patients with and without HIV. Japanese Journal of Infectious Disease, 61 (3). pp. 202-204. ISSN Print: 1344-6304; Online: 1884-2836

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Limited data are available on the relationship between nutritional status and pulmonary tuberculosis (PTB). Zinc plays a vital role in the immune status of the individual. The present study was carried out to estimate serum zinc and albumin levels in newly detected adult active PTB patients with ( n = 20) and without ( n = 20) HIV, and to compare them with the levels in controls (healthy family members; n = 20) who satisfied rigid selection criteria. Standard methods were adopted to collect an early morning fasting blood sample for zinc (by Atomic Absorption Spectrometer) and albumin (estimated by the bromocresol green method). The mean + SD for BMI, zinc and albumin among the controls, HIV positive and HIV negative paitents were 19.6 + 0.6, 18 + 0.4 and 18.5 + 0.6 kg/m 2 ; 117.13 + 4.2, 53.9 + 8 and 65.5 + 9.8 m g/dL; and 4.1 + 0.6, 2.9 + 0.4 and 3.6 + 0.7 g/dL, respectively. All three parameters were signficiantly low in active PTB patients irrespective of HIV status, but more so in HIV-positive individuals. These changes may be attributable to nutritional factors, enteropathy and acute phase reactant proteins. Hence, the National AIDS Control Organization (NACO) in India is providing nutritional supplements to those HIV-infected cases inducted for antiretroviral therapy and nutritional counseling for others as a part of a nutritional policy.

Item Type: Article
Uncontrolled Keywords: Serum, Zinc, Pulmonary, Tuberculosis, HIV, Patients
Subjects: Tuberculosis > Laboratory Research
Tuberculosis > Laboratory Research > Bacteriological
Divisions: Basic Science Research > Bacteriology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 02 Jun 2017 07:44
Last Modified: 02 Jun 2017 07:44

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